Effect of Aluminum on Blood Iron Transport and Zeta Potential. by Rose Winters

I had planned to wait to share this until I could do a better job writing about it, and organize the information in a way that makes it perfectly clear, but I now feel a sense of urgency to share and get some feedback while I have the chance... With the Time article yesterday stating that Facebook should get rid of any pages that speak in a negative way about vaccines, and Zuckerberg taking a stance about the issue, the time may come when I do not have the opportunity to share this. I have spent countless hours working on this, and had planned to spend many more before posting, but I feel there is no time to wait. I do not want to miss the chance to share these ideas with anyone who might be interested or have some information to share with me about it.

The human form is electromagnetic in nature. What happens when we introduce metals into an electromagnetic system? Aluminum is considered "paramagnetic" which means that while aluminum does not create an electrical field on its own, when it comes into a magnetic field, the field is altered. "Paramagnetism refers to the magnetic state of an atom with one or more unpaired electrons. The unpaired electrons are attracted by a magnetic field due to the electrons' magnetic dipole moments."--My understanding is that it is the energy field around the element that interacts with the energy field around another... Aluminum piggy-backs on the iron transport system and is carried in the blood in the same way iron is transported... The hemoglobin in the red blood cells depend on correctly charged iron that is released into the bloodstream and picked up by transferrin which is the body's major iron transport molecule. Under normal conditions, only 1/3 of the iron binding sites on transferrin molecules are occupied. Aluminum has the ability to piggy back on the iron transport system and will fill the unoccupied iron-binding transferrin molecules. Aluminum is positively charged and is always looking to lose an electron. It is high on the reactivity series and often used in the creation of explosives because of the energy available when the extra electron is transferred. When aluminum is transferred through the blood stream and binds to the transferrinreceptors, it permanently damages these receptors... Are the paramagnetic properties of aluminum when introduced into an electromagnetic system actually altering the body's natural magnetism? When the body's magnetism is altered how do the electrical components of the human circuitry that depend on the correctly charged blood respond?

It has been shown that children with autism have abnormally shaped erythrocytes (red blood cells) rather than circular or donut shaped (they need to be able to fold in on themselves to be transferred into the capillaries) they are elliptical and obtuse and lose the ability to fit into the uptake mechanisms that allow for blood flow. The "coagulation" of blood is the result and can lead to strokes because the blood that would normally flow easily to the cells to deliver oxygen is impeded, leaving cells starved of oxygen which is what happens when a person has a stroke. A stroke may not even be noticed while it is happening, especially in a child that can't accurately describe what is happening inside their own body, and permanent brain damage, physical disability can result. Another aspect of autistic children is that they are often "iron deficient"--- While some of this may be due to the damaged gut flora that make it difficult for them to digest food, it is also that they can't use the iron that they do ingest because of permanent damage to the iron transport system. Even iron supplements can't help these children raise their iron levels if the iron can't be carried by the transport system to the cells that require it. **My question: Is it possible that the interaction of the aluminum with the red blood cells (basically hemoglobin/rich in iron) is altering the shape of the cell? If the paramagnetic properties of the interaction between the elements has any sort of attraction/repulsion, then it seems possible that the cell shape could be affected.... the question becomes, are these abnormal cell shapes present at birth, or did something damage them later on?

Another aspect of aluminum in the system is the effect it has on the myelin sheath surrounding nerve endings. In a human being, this sheath (or coating/insulation on the bundle of "wires" known as the nervous system) is built layer by layer, (the wires are "exposed" at birth) and it takes at least 2 full years for a human being to form the insulation (myelin sheath) around their nerves. When the "wires" are exposed, it is similar to a stripped cord that will not only lose electricity on the way to where it is going (which means that it will not reach the desired muscle/tissue that it was meant to control) this lost electricity will reach cells it was never meant to come into contact with, which is sort of like an electrical shock that will cause these cells to "seize"--- when a human is having a seizure, the body is shocking itself, and the cells being shocked have no way to protect themselves. Aluminum is known to strip the myelin sheath and can permanently damage axons in the brain. These axons do not have the ability to repair themselves as the dendrites do, and permanent brain injury can be the result. The messenger system between the nervous system (electrical) and the brain no longer works, the messages do not reach their original target, the child may never be able to use these parts of the brain to obtain normal body function.

Effects of Aluminum -Rose Winters (Part 2)

Aluminum is a mind numbing agent. The aluminum that reaches the brain via the iron transport system may form deposits in critical regions such as the hypothalymus. These aluminum deposits may also destroy gray matter and create permanent brain lesions. The aluminum is corrosive in the brain, it can't be cleared as easily as aluminum that is ingested in the diet that will be processed and mostly excreted by the kidneys. Aluminum deposits have been found in the brains of alzheimer's patients and the characteristics of alzheimers patients is similar to some of the characteristics we are now seeing in children. Alzheimers is not a natural consequence of aging, it is a disorder of the brain, often created by aluminum. Studies on aluminum in the brain reveal that aluminum is capable of creating these symptoms and we need to look at the brains of children and see what aluminum is doing to their entire system.

Aluminum corrodes the circuits that are responsible for all human processes in the human body. The human circuitry depends on the transfer of messages in the form of electrical synapses which initiates the production of chemical neurotransmitters that or move information across ion channels, in order for all systems of the body to work in sync. When the circuits are corroded, the messages get lost somewhere along the line. Often we here parents say that after vaccination, the child just went within themselves and they know their child is still "in there" but the parent can't "reach" the child. Many of these children are poisoned by the neurotoxins in their systems and really can't interact in their environment they way they were originally designed. Their brains and bodies are not receiving the messages necessary to translate information from the environment through their biofeedback mechanisms...

This is serious. Essentially, aluminum fries the brain and the nervous system... Whether a child is experiencing a full disfunction or showing no signs of this disfunction after vaccination, every single aluminum containing vaccine is creating havoc in some way in every single person who takes one. Some people will experience more damage than others because everyone's body is different and many will not show immediate signs of damage. Over time, the toxic overload from aluminum will catch up with everyone, there is only so much a system can handle. Aluminum was never meant to be injected into the system, and the amounts of aluminum a person will have injected into them (beginning on the first day of birth) over the course of a lifetime if they follow the CDC's schedule will create much disease and disorders over the course of that lifetime... The rates of MS, alzheimers, lupus, lou gehrigs, autism, have all skyrocketed and will get worse... It is getting to the point where it is abnormal to be healthy in this world. If forced vaccination becomes the norm, we are looking at a society where there will be few individuals who make it into their golden years and retain full brain/body function.

"Aluminum and other trivalent metals were shown to stimulate uptake of transferrin bound iron and nontransferrinbound iron in erytholeukemia and hepatoma cells. Because of the association between aluminum and Alzheimer's Disease, and findings of higher levels of iron in Alzheimer's disease brains, the effects of aluminum on iron homeostasis were examined in a human glial cell line. Aluminum stimulated dose- and time-dependent uptake of nontransferrin bound iron and iron bound to transferrin. A transporter was likely involved in the uptake of nontransferrin iron because uptake reached saturation, was temperature-dependent, and attenuated by inhibitors of protein synthesis. Interestingly, the effects of aluminum were not blocked by inhibitors of RNA synthesis. Aluminum also decreased the amount of iron bound to ferritin though it did not affect levels of divalent metal transporter 1. These results suggest that aluminum disrupts iron homeostasis in the brain by several mechanisms including the transferrin receptor, a nontransferrin iron transporter, and ferritin." 
Effect of aluminium on iron uptake and transferrin-receptor expression by human erythroleukaemia K562 cells.

"The quantitative variation among patients in their response to erythropoietin can be explained, in part, by factors that can independently cause anemia in patients with end-stage renal disease. Aluminum can blunt the effect of erythropoietin, in part by interfering with iron bioavailability. This inhibitory effect cannot be completely overcome by aggressive ferrotherapy, but can be reversed with aluminum chelation therapy. A patient is described who developed hematological evidence of aluminum excess after being treated with erythropoietin. The biochemical evidence of functional iron deficiency and the response to aluminum chelation therapy support the hypothesis that the inhibitory effect of aluminum on erythropoiesis is mediated by the interference of aluminum with the bioavailability of iron." http://www.ncbi.nlm.nih.gov/pubmed/2239943

Effect of Aluminum -Rose Winters (Part 3)

"The nervous system is a formidable electrical communication network. Communication between the brain and the rest of the body takes place by means of electrical and chemical signals. An electroencephalogram (EEG) records the electrical activity in our brain.

The heart as well features specialised cells that automatically generate electrical impulses. These are the triggers of the electrical activity in the various heart cells, including those that are responsible for heart contractions. An electrocardiogram (ECG) records the overall electrical activity within the heart.

In a copper wire, the current is due to the movement of electrons. In the human body, which consists of water for the most part, the current is caused by the movement of ions. The transmission of an electrical signal from one cell to another is obtained because the distribution of ions is different on either side of the cell wall.

The concentration in positive ions and negative ions is different on either side of the cell membrane: Na+ and Cl- ions are more numerous on the outside of the cell; K+ ions and negatively charged proteins are more numerous inside the cell.

By placing a microsensor inside a cell and another one outside, a potential difference can be measured: at rest, the interior of the cell is more negative than the exterior (between -20 and -100 mV). It is the at rest potential.

Depending on the state of stimulation of the cell, few, many or no ions go through the cell membrane. The difference of potential between the inside and the outside of the cell vary with the movement of the ions. Beyond a certain threshold, the cell triggers the action potential.

Excitable cells (such as neurons, heart and muscle cells) have the ability to quickly change the intra- and extracellular ionic concentrations, thus initiating cycles of depolarization and repolarization. In the neuron shown below, the action potential triggered in the body of the neuron travels along the axon in order to signal to the biceps that it must contract.

At the nerve terminations in contact with the muscle (synapses in this case), the electrical signal is converted to a chemical signal: the action potential releases certain molecules (called neurotransmitters) which represent information the muscle can understand.

The intensity of the action potentials is very low, but thousands of them travel through the human body neurons all the time. Their travelling speed (*) depends on the axons characteristics, such as their cross section and whether or not they have a myelin sheath." http://www.bbemg.be/en/main-emf/electricity-fields/electrical-concepts.html

The combination of erythrocyte shape abnormalities, erythrocyte membrane oxidative damage, and β-actinalterations constitutes a previously unrecognized triad in classical autism and provides new biological markers in the diagnostic workup of ASDs." http://www.ncbi.nlm.nih.gov/pubmed/24453417

"Disturbances in metal-ion transport, homeostasis, overload and metal ion-mediated catalysis are implicated in neurodegenerative conditions such as Alzheimer's disease (AD). The mechanisms of metal-ion induced disruption of genetic function, termed genotoxicity, are not well understood. In these experiments we examined the effects of non-apoptotic concentrations of magnesium-, iron- and aluminum-sulfate on gene expression patterns in untransformed human neural (HN) cells in primary culture using high density DNA array profiling and Western immunoassay. Two week old HN cells were exposed to low micromolar magnesium, iron, or aluminum for 7 days, representing trace metal exposure over one-third of their lifespan. While total RNA yield and abundance were not significantly altered, both iron and aluminum were found to induce HSP27, COX-2, betaAPP and DAXX gene expression. Similarly up-regulated gene expression for these stress-sensing, pro-inflammatory and pro-apoptotic elements have been observed in AD brain. The combination of iron and aluminum together was found to be particularly effective in up-regulating these genes, and was preceded by the evolution of reactive oxygen intermediates as measured by 2',7'-dichlorofluorescein diacetate assay. These data indicate that physiologically relevant amounts of iron and aluminum are capable of inducing Fenton chemistry-triggered gene expression programs that may support downstream pathogenic responses and brain cell dysfunction." http://www.ncbi.nlm.nih.gov/pubmed/16308480

Effect of Aluminum -Rose Winters (Part 4)

"Iron has an important role on cognitive, behavioral, and motor development. High prevalence of iron deficiency has been reported in autism. The aim of this study was to investigate iron status in a group of children with autistic disorder. The sample was composed of 116 children between 3 and 16 years with a diagnosis of autistic disorder according to DSM-IV criteria. Serum ferritin, iron, hemoglobin, hematocrit, mean corpuscular volume, and red cell distribution width values were measured. We found that 24.1% of subjects had iron deficiency, and 15.5% had anemia. There was a significant positive correlation between age and ferritin and hematological measures. Results of this study confirmed that iron deficiency and anemia are common in children with autistic disorder." http://www.ncbi.nlm.nih.gov/pubmed/21643649

Human serum transferrin: is there a link among autism, high oxalate levels, and iron deficiency anemia?

"It has been previously suggested that large amounts of oxalate in plasma could play a role in autism by binding to the bilobal iron transport protein transferrin (hTF), thereby interfering with iron metabolism by inhibiting the delivery of iron to cells. By examining the effect of the substitution of oxalate for the physiologically utilized synergistic carbonate anion in each lobe of hTF, we sought to provide a molecular basis for or against such a role. Our work clearly shows both qualitatively (6 M urea gels) and quantitatively (kinetic analysis by stopped-flow spectrofluorimetry) that the presence of oxalate in place of carbonate in each binding site of hTF does indeed greatly interfere with the removal of iron from each lobe (in the absence and presence of the specific hTFreceptor). However, we also clearly demonstrate that once the iron is bound within each lobe of hTF, neither anion can displace the other. Additionally, as verified by urea gels and electrospray mass spectrometry, formation of completely homogeneous hTF-anion complexes requires that all iron must first be removed and hTF then reloaded with iron in the presence of either carbonate or oxalate. Significantly, experiments described here show that carbonate is the preferred binding partner; i.e., even if an equal amount of each anion is available during the iron loading process, the hTF-carbonate complex is formed."

Human serum transferrin: is there a link among autism, high oxalate levels, and iron deficiency anemia?Biochemistry. 2013 Nov 19;52(46):8333-41. doi: 10.1021/bi401190m. Epub 2013 Nov 8

Erythrocyte shape abnormalities, membrane oxidative damage, and β-actin alterations: an unrecognized triad in classical autism. Mediators of Inflammation 2013;2013:432616. doi: 10.1155/2013/432616. Epub 2013 Dec 21.

http://www.toxipedia.org/display/toxipedia/Neurotoxins
"Certain heavy metals have been reported to seriously affect the immune system potentially resulting in a broad range of harmful health effects. Reported alterations in immune cell function include a variety of affected mechanisms. Thereby, depending on the particular metal, its concentration, route and duration of exposure, and biologic availability, the net outcome may be either immunosuppression or stimulation of immune cell activity. Since the key importance of the immune system is protection of the host against pathogenic agents, an impaired immune competence inevitably increases the susceptibility to invading pathogens. However, being aware that the immune system represents a sensitively regulated network of different cells, tissues, and soluble mediators it has to be stated that any form of dys-regulation may result in adverse health effects with overstimulation being as harmful as inhibition of functional activity. Chronic-inflammatory reactions, cancer development, hypersensitivity, allergic and autoimmune diseases are known consequences of persisting overstimulation. All these manifestations were already found to be related with heavy metal exposure." Metal ions affecting the immune system. Met Ions Life Sci. 2011;8:157-85.

Neurophysiological findings and serum aluminium in dialysis encephalopathy
"64 patients on hemodialysis were investigated. The mean duration of dialysis was 43 months. In all the patients, serum aluminium levels, systolic blood pressure (averaged over a period of 6 weeks) and the EEG were investigated. Psychological testing to assess the level of intelligence (IQ) was also performed. The serum aluminium levels have been assayed by flameless atomic absorption (Perkin-Elmer atomic absorption spectrophotometer model 420). In 6 patients, the diagnosis of dementia was made on the basis of psychological testing and clinical observations. The demented patients showed significantly (p less than 0.01) higher aluminiumlevels (mean 409 microgram/l, SD 235) than the 58 non-demented patients (mean 189 microgram/l, SD 152), whereas the age of the patients, duration of dialysis and blood pressure were the same in both groups. The EEG was abnormal in all 6 demented patients. Only in 23 of the 58 non-demented patients was the EEG pathological (p less than 0.05). A significant correlation was found between serum aluminium levels and the EEG data with regard to bilateral slow waves, focal slow waves and epileptic potentials (p less than 0.05). The EEG, age of the patients, duration of dialysis and blood pressure showed no correlation. Electromyography, nerve conduction velocity and latency showed no correlation with aluminium levels or dementia. It can be concluded from our findings that in dialyzed patients there is a correlation between serum aluminium levels and the appearance of dementia and EEG changes." http://www.ncbi.nlm.nih.gov/pubmed/7117320

Aluminium impairs the glutamate-nitric oxide-cGMP pathway in cultured neurons and in rat brain in vivo: molecular mechanisms and implications for neuropathology.

"Aluminium (Al) is a neurotoxicant and appears as a possible etiological factor in Alzheimer's disease and other neurological disorders. The mechanisms of Al neurotoxicity are presently unclear but evidence has emerged suggesting that Al accumulation in the brain can alter neuronal signal transduction pathways associated with glutamate receptors. In cerebellar neurons in culture, long term-exposure to Al added 'in vitro' impaired the glutamate-nitric oxide (NO)-cyclic GMP (cGMP) pathway, reducing glutamate-induced activation of NO synthase and NO-induced activation of the cGMP generating enzyme, guanylate cyclase. Prenatal exposure to Al also affected strongly the function of the glutamate-NO-cGMP pathway. In cultured neurons from rats prenatally exposed to Al, we found reduced content of NO synthase and of guanylate cyclase, and a dramatic decrease in the ability of glutamate to increase cGMP formation. Activation of the glutamate-NO-cGMP pathway was also strongly impaired in cerebellum of rats chronically treated with Al, as assessed by in vivo brain microdialysis in freely moving rats. These findings suggest that the impairment of the Glu-NO-cGMP pathway in the brain may be responsible for some of the neurological alterations induced by Al." http://www.ncbi.nlm.nih.gov/pubmed/11709215

"Essential to iron homeostasis is the transport of iron by the bilobal protein human serum transferrin (hTF). Each lobe (N- and C-lobe) of hTF forms a deep cleft which binds a single Fe(3+). Iron-bearing hTF in the blood binds tightly to the specific transferrin receptor (TFR), a homodimeric transmembrane protein. After undergoing endocytosis, acidification of the endosome initiates the release of Fe(3+) from hTF in a TFR-mediated process. Iron-free hTF remains tightly bound to the TFR at acidic pH; following recycling back to the cell surface, it is released to sequester more iron. Efficient delivery of iron is critically dependent on hTF/TFR interactions. Therefore, identification of the pH-specific contacts between hTF and the TFR is crucial. Recombinant protein production has enabled deconvolution of this complex system. The studies reviewed herein support a model in which pH-induced interrelated events control receptor-stimulated iron release from each lobe of hTF." http://www.ncbi.nlm.nih.gov/pubmed/23046645

Toxic Accumulation of Aluminum in Individuals Receiving TPN (IV Nutrition)

They use scare tactics, manipulation, and treat you like you're an idiot to scare parents into vaccines. If they really work then let the facts speak for themselves and in all my research the facts speak loudly that this is a dangerous poison being forced into our innocent children. For one example let me just show you what the FDA says (not that they are trustworthy but they just shot CDC and vaccines with this one). According to the FDA: "Aluminum may reach toxic levels with prolonged parenteral administration [this means injected into the body] if kidney function is impaired... Research indicates that patients with impaired kidney function, including premature neonates [babies], who received parenteral levels of aluminum at greater than 4 to 5 micrograms per kilogram of body weight per day, accumulate aluminum at levels associated with central nervous system and bone toxicity [for a tiny newborn, this toxic dose would be 10 to 20 micrograms, and for an adult it would be about 350 micrograms]. Tissue loading may occur at even lower rates of administration." [Department of Health and Human Services, Food and Drug Administration, Document NDA 19-626/S-019, Federal Food, Drug and Cosmetic Act for Dextrose Injections.]

"Aluminum content in parenteral drug products could result in a toxic accumulation of aluminum in individuals receiving TPN therapy. Research indicates that neonates [newborns] and patient populations with impaired kidney function may be at high risk of exposure to unsafe amounts of aluminum. Studies show that aluminum may accumulate in the bone, urine, and plasma of infants receiving TPN. Many drug products used in parenteral therapy [injections] may contain levels of aluminum sufficiently high to cause clinical manifestations [symptoms]... parenteral aluminum bypasses the protective mechanism of the GI tract and aluminum circulates and is deposited in human tissues. Aluminum toxicity is difficult to identify in infants because few reliable techniques are available to evaluate bone metabolism in... infants... Although aluminum toxicity is not commonly detected clinically, it can be serious in selected patient populations, such as neonates [newborns], and may be more common than is recognized." [Department of Health and Human Services, Food and Drug Administration, Document 02N-0496, Aluminum in Large and Small Volume Parenterals Used in Total Parenteral Nutrition. Available online at: Aluminum in Large and Small Volume Parenterals]

So basically from those documents we learn that if a premature baby receives more than 10 mcg of aluminum in an IV, it can accumulate in their bones and brain, and can be toxic.

The FDA maximum requirements for aluminum received in an IV is 25 mcg per day. The suggested aluminum per kg of weight to give to a person is up to 5mcg. (so a 5 pounds baby should get no more than 11mcg of aluminum.) Anything that has more than 25 mcg of aluminum is supposed to have a label that says: WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Aluminum Toxicity in Infants and Children

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 [micro]g/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration. [CFR - Code of Federal Regulations Title 21]

Vaccines, for some reason, are not required to have this label and also are not required to follow the maximum dosage of 25 mcg. At birth, most children are given the hepatitis B vaccination. The amount of aluminum in the Hepatitis B vaccine alone is almost 14 times the maximum FDA "safe" level.

At well-child check-ups, it's common for 2 month, 4 month, 6 month etc., appointments to include up to 8 vaccinations that add up to more than 1,000 mcg of aluminum. Look at the chart above and notice that that amount isn't even safe for a 350 pound adult. And many children get up to 8 vaccinations a visit several times a year!

According to the FDA and the AAP (American Academy of Pediatrics), what happens if a child receives more than the maximum required dose of aluminum?

Aluminum builds up in the bones and brain and can be toxic.
Aluminum can cause neurological harm. Aluminum overdose can be fatal in patients with weak kidneys or kidney disorders or in premature babies. (How many children are tested to see if their kidneys are functioning properly before they are vaccinated? Could this also be why the Hepatitis B shot, given to infants at birth, has been linked to SIDS? Neonatal Deaths After Hep B vaccination.)
[Aluminum Toxicity in Infants and Children, Committee on Nutrition,American Academy of Pediatrics, Pediatrics Volume 97, Number 3 March, 1996, pp. 413-416]